{"id":5118,"date":"2026-06-08T02:22:05","date_gmt":"2026-06-08T02:22:05","guid":{"rendered":"https:\/\/researcher.life\/blog\/?p=5118"},"modified":"2026-06-08T09:26:11","modified_gmt":"2026-06-08T09:26:11","slug":"what-is-p-value-calculation-statistical-significance","status":"publish","type":"post","link":"https:\/\/researcher.life\/blog\/article\/what-is-p-value-calculation-statistical-significance\/","title":{"rendered":"What is p-value: How to Calculate It and Statistical Significance"},"content":{"rendered":"<p>\u201cWhat is a p-value?\u201d are words often uttered by early career researchers and sometimes even by more experienced ones. The p-value is an important and frequently used concept in quantitative research. It can also be confusing and easily misused. In this article, we delve into what is a p-value, how to calculate it, and its statistical significance.<\/p>\n<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_68 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title \" >Table of Contents<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/researcher.life\/blog\/article\/what-is-p-value-calculation-statistical-significance\/#What_is_a_p-value\" title=\"What is a p-value\">What is a p-value<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/researcher.life\/blog\/article\/what-is-p-value-calculation-statistical-significance\/#What_is_a_null_hypothesis\" title=\"What is a null hypothesis\">What is a null hypothesis<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/researcher.life\/blog\/article\/what-is-p-value-calculation-statistical-significance\/#How_to_calculate_p-values\" title=\"How to calculate p-values\">How to calculate p-values<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-4\" href=\"https:\/\/researcher.life\/blog\/article\/what-is-p-value-calculation-statistical-significance\/#P-Value_and_statistical_significance\" title=\"P-Value and statistical significance\">P-Value and statistical significance<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-5\" href=\"https:\/\/researcher.life\/blog\/article\/what-is-p-value-calculation-statistical-significance\/#P-value_table\" title=\"P-value table\">P-value table<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-6\" href=\"https:\/\/researcher.life\/blog\/article\/what-is-p-value-calculation-statistical-significance\/#How_to_report_p-values_in_research\" title=\"How to report p-values in research\">How to report p-values in research<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-7\" href=\"https:\/\/researcher.life\/blog\/article\/what-is-p-value-calculation-statistical-significance\/#How_one_can_use_p-value_to_compare_two_different_results_of_a_hypothesis_test\" title=\"How one can use p-value to compare two different results of a hypothesis test?\">How one can use p-value to compare two different results of a hypothesis test?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-8\" href=\"https:\/\/researcher.life\/blog\/article\/what-is-p-value-calculation-statistical-significance\/#Why_just_using_p-values_is_not_enough_while_interpreting_two_different_variables\" title=\"Why just using p-values is not enough while interpreting two different variables\">Why just using p-values is not enough while interpreting two different variables<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-9\" href=\"https:\/\/researcher.life\/blog\/article\/what-is-p-value-calculation-statistical-significance\/#Things_to_consider_while_using_p-values\" title=\"Things to consider while using p-values\">Things to consider while using p-values<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-10\" href=\"https:\/\/researcher.life\/blog\/article\/what-is-p-value-calculation-statistical-significance\/#One-Tailed_vs_Two-Tailed_Tests\" title=\"One-Tailed vs Two-Tailed Tests\">One-Tailed vs Two-Tailed Tests<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-11\" href=\"https:\/\/researcher.life\/blog\/article\/what-is-p-value-calculation-statistical-significance\/#Choosing_between_them\" title=\"Choosing between them\">Choosing between them<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-12\" href=\"https:\/\/researcher.life\/blog\/article\/what-is-p-value-calculation-statistical-significance\/#Confidence_Intervals\" title=\"Confidence Intervals\">Confidence Intervals<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-13\" href=\"https:\/\/researcher.life\/blog\/article\/what-is-p-value-calculation-statistical-significance\/#What_is_a_confidence_interval\" title=\"What is a confidence interval?\">What is a confidence interval?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-14\" href=\"https:\/\/researcher.life\/blog\/article\/what-is-p-value-calculation-statistical-significance\/#What_does_a_95_confidence_interval_mean\" title=\"What does a 95% confidence interval mean?\">What does a 95% confidence interval mean?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-15\" href=\"https:\/\/researcher.life\/blog\/article\/what-is-p-value-calculation-statistical-significance\/#How_confidence_intervals_relate_to_p-values\" title=\"How confidence intervals relate to p-values\">How confidence intervals relate to p-values<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-16\" href=\"https:\/\/researcher.life\/blog\/article\/what-is-p-value-calculation-statistical-significance\/#Why_confidence_intervals_matter\" title=\"Why confidence intervals matter\">Why confidence intervals matter<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-17\" href=\"https:\/\/researcher.life\/blog\/article\/what-is-p-value-calculation-statistical-significance\/#Type_I_and_Type_II_Errors\" title=\"Type I and Type II Errors\">Type I and Type II Errors<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-18\" href=\"https:\/\/researcher.life\/blog\/article\/what-is-p-value-calculation-statistical-significance\/#What_is_a_Type_I_error\" title=\"What is a Type I error?\">What is a Type I error?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-19\" href=\"https:\/\/researcher.life\/blog\/article\/what-is-p-value-calculation-statistical-significance\/#What_is_a_Type_II_error\" title=\"What is a Type II error?\">What is a Type II error?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-20\" href=\"https:\/\/researcher.life\/blog\/article\/what-is-p-value-calculation-statistical-significance\/#The_trade-off_between_error_types\" title=\"The trade-off between error types\">The trade-off between error types<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-21\" href=\"https:\/\/researcher.life\/blog\/article\/what-is-p-value-calculation-statistical-significance\/#Practical_implications\" title=\"Practical implications\">Practical implications<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-22\" href=\"https:\/\/researcher.life\/blog\/article\/what-is-p-value-calculation-statistical-significance\/#Statistical_Power\" title=\"Statistical Power\">Statistical Power<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-23\" href=\"https:\/\/researcher.life\/blog\/article\/what-is-p-value-calculation-statistical-significance\/#What_determines_statistical_power\" title=\"What determines statistical power?\">What determines statistical power?<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-24\" href=\"https:\/\/researcher.life\/blog\/article\/what-is-p-value-calculation-statistical-significance\/#Why_power_matters\" title=\"Why power matters\">Why power matters<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-25\" href=\"https:\/\/researcher.life\/blog\/article\/what-is-p-value-calculation-statistical-significance\/#Power_analysis\" title=\"Power analysis\">Power analysis<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-26\" href=\"https:\/\/researcher.life\/blog\/article\/what-is-p-value-calculation-statistical-significance\/#The_Multiple_Comparisons_Problem\" title=\"The Multiple Comparisons Problem\">The Multiple Comparisons Problem<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-27\" href=\"https:\/\/researcher.life\/blog\/article\/what-is-p-value-calculation-statistical-significance\/#Why_multiple_tests_inflate_the_false_positive_rate\" title=\"Why multiple tests inflate the false positive rate\">Why multiple tests inflate the false positive rate<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-28\" href=\"https:\/\/researcher.life\/blog\/article\/what-is-p-value-calculation-statistical-significance\/#ANOVA_vs_multiple_t-tests\" title=\"ANOVA vs multiple t-tests\">ANOVA vs multiple t-tests<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-29\" href=\"https:\/\/researcher.life\/blog\/article\/what-is-p-value-calculation-statistical-significance\/#Common_corrections\" title=\"Common corrections\">Common corrections<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-30\" href=\"https:\/\/researcher.life\/blog\/article\/what-is-p-value-calculation-statistical-significance\/#Publication_Bias_and_the_Replication_Crisis\" title=\"Publication Bias and the Replication Crisis\">Publication Bias and the Replication Crisis<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-31\" href=\"https:\/\/researcher.life\/blog\/article\/what-is-p-value-calculation-statistical-significance\/#Publication_bias\" title=\"Publication bias\">Publication bias<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-32\" href=\"https:\/\/researcher.life\/blog\/article\/what-is-p-value-calculation-statistical-significance\/#The_replication_crisis\" title=\"The replication crisis\">The replication crisis<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-33\" href=\"https:\/\/researcher.life\/blog\/article\/what-is-p-value-calculation-statistical-significance\/#What_this_means_for_interpreting_p-values\" title=\"What this means for interpreting p-values\">What this means for interpreting p-values<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-34\" href=\"https:\/\/researcher.life\/blog\/article\/what-is-p-value-calculation-statistical-significance\/#Reporting_non-significant_results\" title=\"Reporting non-significant results\">Reporting non-significant results<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-35\" href=\"https:\/\/researcher.life\/blog\/article\/what-is-p-value-calculation-statistical-significance\/#Pre-registration_and_the_methods_section\" title=\"Pre-registration and the methods section\">Pre-registration and the methods section<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-36\" href=\"https:\/\/researcher.life\/blog\/article\/what-is-p-value-calculation-statistical-significance\/#Reporting_P-Values_in_APA_Format\" title=\"Reporting P-Values in APA Format\">Reporting P-Values in APA Format<\/a><ul class='ez-toc-list-level-3' ><li class='ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-37\" href=\"https:\/\/researcher.life\/blog\/article\/what-is-p-value-calculation-statistical-significance\/#General_formatting_rules\" title=\"General formatting rules\">General formatting rules<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-3'><a class=\"ez-toc-link ez-toc-heading-38\" href=\"https:\/\/researcher.life\/blog\/article\/what-is-p-value-calculation-statistical-significance\/#What_to_report_alongside_the_p-value\" title=\"What to report alongside the p-value\">What to report alongside the p-value<\/a><\/li><\/ul><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-39\" href=\"https:\/\/researcher.life\/blog\/article\/what-is-p-value-calculation-statistical-significance\/#Worked_example_independent_samples_t-test\" title=\"Worked example: independent samples t-test\">Worked example: independent samples t-test<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-40\" href=\"https:\/\/researcher.life\/blog\/article\/what-is-p-value-calculation-statistical-significance\/#Frequently_Asked_Questions_FAQs_on_p-value\" title=\"Frequently Asked Questions (FAQs) on p-value\u00a0\">Frequently Asked Questions (FAQs) on p-value\u00a0<\/a><\/li><\/ul><\/nav><\/div>\n<h2><span class=\"ez-toc-section\" id=\"What_is_a_p-value\"><\/span><strong>What is a p-value<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>The p-value, or probability value, is the probability that your results occurred randomly given that the null hypothesis is true. P-values are used in hypothesis testing to find evidence that differences in values or groups exist. P-values are determined through the calculation of the test statistic for the test you are using and are based on the assumed or known probability distribution.<\/p>\n<p>For example, you are researching a new pain medicine that is designed to last longer than the current commonly prescribed drug. Please note that this is an extremely simplified example, intended only to demonstrate the concepts. From previous research, you know that the underlying probability distribution for both medicines is the normal distribution, which is shown in the figure below.<\/p>\n<figure id=\"attachment_5119\" aria-describedby=\"caption-attachment-5119\" style=\"width: 1324px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-5119 size-full\" src=\"https:\/\/blog.researcher.life\/wp-content\/uploads\/2023\/02\/hero5.png\" alt=\"What is p-value: How to calculate it and statistical significance \" width=\"1324\" height=\"838\" srcset=\"https:\/\/blog.researcher.life\/wp-content\/uploads\/2023\/02\/hero5.png 1324w, https:\/\/blog.researcher.life\/wp-content\/uploads\/2023\/02\/hero5-300x190.png 300w, https:\/\/blog.researcher.life\/wp-content\/uploads\/2023\/02\/hero5-1024x648.png 1024w, https:\/\/blog.researcher.life\/wp-content\/uploads\/2023\/02\/hero5-768x486.png 768w\" sizes=\"auto, (max-width: 1324px) 100vw, 1324px\" \/><figcaption id=\"caption-attachment-5119\" class=\"wp-caption-text\">P-values are used in hypothesis testing to find evidence that differences in values or groups exist.<\/figcaption><\/figure>\n<p>You are planning a <a href=\"https:\/\/www.editage.com\/insights\/a-young-researchers-guide-to-a-clinical-trial\" target=\"_blank\" rel=\"noopener\">clinical trial<\/a> for your drug. If your results show that the average length of time patients are pain-free is longer for the new drug than that for the standard medicine, how will you know that this is not just a random outcome? If this result falls within the green shaded area of the graph, you may have evidence that your drug has a longer effect. But how can we determine this scientifically? We do this through <a href=\"https:\/\/www.editage.com\/blog\/hypothesis-testing-different-types-for-biomedical-researchers\/\" target=\"_blank\" rel=\"noopener\">hypothesis testing<\/a>.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"What_is_a_null_hypothesis\"><\/span><strong>What is a null hypothesis<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Stating your null and alternative hypotheses is the first step in conducting a hypothesis test. The <a href=\"https:\/\/www.editage.com\/insights\/the-null-hypothesis-what-researchers-often-get-wrong\" target=\"_blank\" rel=\"noopener\">null hypothesis<\/a> (H<sub>0<\/sub>) is what you\u2019re trying to disprove, usually a statement that there is no relationship between two variables or no difference between two groups. The alternative hypothesis (H<sub>a<\/sub>) states that a relationship exists or that there is a difference between two groups. It represents what you\u2019re trying to find evidence to support.<\/p>\n<p>Before we conduct the clinical trial, we <a href=\"https:\/\/www.editage.com\/insights\/everything-you-need-to-know-about-framing-a-research-hypothesis\" target=\"_blank\" rel=\"noopener\">create the following hypotheses<\/a>:<\/p>\n<p>H<sub>0<\/sub>: the mean longevity of the new drug is equal to that of the standard drug<\/p>\n<p>H<sub>a<\/sub>: the mean longevity of the new drug is greater than that of the standard drug<\/p>\n<p>Note that the null hypothesis states that there is no difference in the mean values for the two drugs. Because H<sub>a<\/sub> includes \u201cgreater than,\u201d this is an upper-tailed test. We are not interested in the area under the lower side of the curve.<\/p>\n<p>Next, we need to determine our criterion for deciding whether or not the null hypothesis can be rejected. This is where the critical p-value comes in. If we assume the null hypothesis is true, how much longer does the new drug have to last?<\/p>\n<p><a href=\"https:\/\/researcher.life\/all-access-pricing?utm_source=contentmarketing&amp;utm_medium=rblog&amp;utm_campaign=what-is-p-value-calculation-statistical-significance-aap-banner1\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-9684 size-large\" src=\"https:\/\/blog.researcher.life\/wp-content\/uploads\/2023\/03\/AAP-Banner-1-1024x410.png\" alt=\"\" width=\"640\" height=\"256\" srcset=\"https:\/\/blog.researcher.life\/wp-content\/uploads\/2023\/03\/AAP-Banner-1-1024x410.png 1024w, https:\/\/blog.researcher.life\/wp-content\/uploads\/2023\/03\/AAP-Banner-1-300x120.png 300w, https:\/\/blog.researcher.life\/wp-content\/uploads\/2023\/03\/AAP-Banner-1-768x307.png 768w, https:\/\/blog.researcher.life\/wp-content\/uploads\/2023\/03\/AAP-Banner-1-1536x615.png 1536w, https:\/\/blog.researcher.life\/wp-content\/uploads\/2023\/03\/AAP-Banner-1-2048x820.png 2048w\" sizes=\"auto, (max-width: 640px) 100vw, 640px\" \/><\/a><\/p>\n<p>Let\u2019s say your results show that the new drug lasts twice as long as the standard drug. In theory, this could still be a random outcome, due to chance, even if the null hypothesis were true. However, at some point, you must consider that the new drug may just have a better longevity. The researcher will typically set that point, which is the probability of rejecting the null hypothesis given that it is true, prior to conducting the trial. This is the critical p-value. Typically, this value is set at <em>p<\/em> = .05, although, depending on the circumstances, it could be set at another value, such as .10 or .01.<\/p>\n<p>Another way to consider the null hypothesis that might make the concept clearer is to compare it to the adage \u201cinnocent until proven guilty.\u201d It is assumed that the null hypothesis is true unless enough strong evidence can be found to disprove it. Statistically significant p-value results can provide some of that evidence, which makes it important to know how to calculate p-values.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"How_to_calculate_p-values\"><\/span><strong>How to calculate p-values<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>The p-value that is determined from your results is based on the test statistic, which depends on the type of hypothesis test you are using. That is because the p-value is actually a probability, and its value, and calculation method, depends on the underlying probability distribution. The p-value also depends in part on whether you are conducting a lower-tailed test, upper-tailed test, or two-tailed test.<\/p>\n<p>The actual p-value is calculated by integrating the probability distribution function to find the relevant areas under the curve using integral calculus. This process can be quite complicated. Fortunately, p-values are usually determined by using tables, which use the test statistic and degrees of freedom, or statistical software, such as SPSS, SAS, or R.<\/p>\n<p>For example, with the simplified clinical test we are performing, we assumed the underlying probability distribution is normal; therefore, we decide to conduct a t-test to test the null hypothesis. The resulting t-test statistic will indicate where along the x-axis, under the normal curve, our result is located. The p-value will then be, in our case, the area under the curve to the right of the test statistic.<\/p>\n<p>Many factors affect the hypothesis test you use and therefore the test statistic. Always make sure to use the test that best fits your data and the relationship you\u2019re testing. The sample size and number of independent variables you use will also impact the p-value.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"P-Value_and_statistical_significance\"><\/span><strong>P-Value and statistical significance<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>You have completed your clinical trial and have determined the p-value. What\u2019s next? How can the result be interpreted? What does a statistically significant result mean?<\/p>\n<p>A statistically significant result means that the p-value you obtained is small enough that the result is not likely to have occurred by chance. P-values are reported in the range of 0\u20131, and the smaller the p-value, the less likely it is that the null hypothesis is true and the greater the indication that it can be rejected. The critical p-value, or the point at which a result can be considered to be statistically significant, is set prior to the experiment.<\/p>\n<p>In our simplified clinical trial example, we set the critical p-value at 0.05. If the p-value obtained from the trial was found to be <em>p<\/em> = .0375, we can say that the results were statistically significant, and we have evidence for rejecting the null hypothesis. However, this does not mean that we can be absolutely certain that the null hypothesis is false. The results of the test only indicate that the null hypothesis is likely false.<strong>\u00a0<\/strong><\/p>\n<p><a href=\"https:\/\/app.adjust.net.in\/e73v6e9\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-5399 size-full\" src=\"https:\/\/blog.researcher.life\/wp-content\/uploads\/2023\/03\/03_RDiscovery_BlogBanner_640x139px-1.png\" alt=\"\" width=\"640\" height=\"139\" srcset=\"https:\/\/blog.researcher.life\/wp-content\/uploads\/2023\/03\/03_RDiscovery_BlogBanner_640x139px-1.png 640w, https:\/\/blog.researcher.life\/wp-content\/uploads\/2023\/03\/03_RDiscovery_BlogBanner_640x139px-1-300x65.png 300w\" sizes=\"auto, (max-width: 640px) 100vw, 640px\" \/><\/a><\/p>\n<h2><span class=\"ez-toc-section\" id=\"P-value_table\"><\/span><strong>P-value table<\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>So, how can we interpret the p-value results of an experiment or trial? A p-value table, prepared prior to the experiment, can sometimes be helpful. This table lists possible p-values and their interpretations.<\/p>\n<table>\n<tbody>\n<tr>\n<td width=\"312\">P-value range<\/td>\n<td width=\"312\">Interpretation<\/td>\n<\/tr>\n<tr>\n<td width=\"312\"><em>p<\/em> &gt; 0.05<\/td>\n<td width=\"312\">Results are not statistically significant; do not reject the null hypothesis<\/td>\n<\/tr>\n<tr>\n<td width=\"312\"><em>p<\/em> &lt; 0.05<\/td>\n<td width=\"312\">Results are statistically significant; in general, reject the null hypothesis<\/td>\n<\/tr>\n<tr>\n<td width=\"312\"><em>p &lt; <\/em>0.01<\/td>\n<td width=\"312\">Results are highly statistically significant; reject the null hypothesis<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h2><span class=\"ez-toc-section\" id=\"How_to_report_p-values_in_research\"><\/span><strong>How to report p-values in research <\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>P-values, like all experimental outcomes, are usually reported in the results section, and sometimes in the abstract, of a research paper. Enough information also needs to be provided so that the readers can place the p-values into context. For our example, the test statistic and effect size should also be included in the results.<\/p>\n<p>To enable readers to clearly understand your results, the significance threshold you used, the critical p-value should be reported in <a href=\"https:\/\/www.editage.com\/insights\/how-to-write-the-methods-section-of-a-research-paper\" target=\"_blank\" rel=\"noopener\">the methods section of your paper<\/a>. For our example, we might state that \u201cIn this study, the statistical threshold was set at <em>p<\/em> = .05.\u201d The sample sizes<a href=\"https:\/\/www.editage.com\/insights\/an-introduction-to-sample-size-effect-size-and-statistical-power-for-biomedical-researchers\" target=\"_blank\" rel=\"noopener\">https:\/\/www.editage.com\/insights\/an-introduction-to-sample-size-effect-size-and-statistical-power-for-biomedical-researchers<\/a> and assumptions should also be discussed there as they will greatly impact the p-value.<\/p>\n<h3><span class=\"ez-toc-section\" id=\"How_one_can_use_p-value_to_compare_two_different_results_of_a_hypothesis_test\"><\/span><strong>How one can use p-value to compare two different results of a hypothesis test? <\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>What if we conduct two <a href=\"https:\/\/www.editage.com\/blog\/types-of-experimental-research-designs\/\" target=\"_blank\" rel=\"noopener\">experiments<\/a> using the same null and alternative hypotheses? Or what if we conduct the same clinical trial twice with different drugs? Can we use the resulting p-values to compare them?<\/p>\n<p>In general, it is not a good idea to compare results using only p-values. A p-value only reflects the probability that those specific results occurred by chance; it is not related at all to any other results and does not indicate degree. So, just because you obtained a p-value of .04 in with one drug and a value of .025 in with a second drug does not necessarily mean that the second drug is better.<\/p>\n<p>Using p-values to compare two different results may be more feasible if the experiments are exactly the same and all other conditions are controlled except for the one being studied. However, so many different factors impact the p-value that it would be difficult to control them all.<\/p>\n<h3><span class=\"ez-toc-section\" id=\"Why_just_using_p-values_is_not_enough_while_interpreting_two_different_variables\"><\/span><strong>Why just using p-values is not enough while interpreting two different variables <\/strong><span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>P-values can indicate whether or not the null hypothesis should be rejected; however, p-values alone are not enough to show the relative size differences between groups. Therefore, both the statistical significance and the effect size should be reported when discussing the results of a study.<\/p>\n<p>For example, suppose the sample size in our clinical trials was very large, maybe 1,000, and we found the p-value to be .035. The difference between the two drugs is statistically significant because the p-value was less than .05. However, if we looked at the difference in the actual times the drugs were effective, we might find that the new drug lasted only 2 minutes longer than the standard drug. Large sample sizes generally show even very small differences to be significant. We would need this information to make any recommendations based on the results of the trial.<\/p>\n<p>Statistical significance, or p-values, are dependent on both sample size and effect size. Therefore, they all need to be reported for readers to clearly understand the results.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Things_to_consider_while_using_p-values\"><\/span><strong>Things to consider while using p-values <\/strong><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>P-values are very useful tools for researchers. However, much care must be taken to avoid treating them as black and white indicators of a study\u2019s results or misusing them. Here are a few other things to consider when using p-values:<\/p>\n<ul>\n<li>When using p-values in your research report, it\u2019s a good idea to pay attention to your target journal\u2019s guidelines on formatting. Typically, p-values are written without a leading zero. For example, write <em>p<\/em> = .01 instead of <em>p<\/em> = 0.01. Also, p-values, like all other variables, are usually italicized, and spaces are included on both sides of the equal sign.<\/li>\n<li>The significance threshold needs to be set prior to the experiment being conducted. Setting the significance level after looking at the data to ensure a positive result is considered unethical.<\/li>\n<li>P-values have nothing to say about the alternative hypothesis. If your results indicate that the null hypothesis should be rejected, it does not mean that you accept the alternative hypothesis.<\/li>\n<li>P-values never prove anything. All they can do is provide evidence to support rejecting or not rejecting the null hypothesis. Statistics are extremely non-committal.<\/li>\n<li>\u201cNonsignificant\u201d is the opposite of significant. Never report that the results were \u201cinsignificant.&#8221;<\/li>\n<\/ul>\n<h2 aria-level=\"2\"><a href=\"https:\/\/paperpal.com\/?utm_source=contentmarketing&amp;utm_medium=r-blog&amp;utm_campaign=hero-article-p-value-paperpal-banner1\"><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter wp-image-5462 size-full\" src=\"https:\/\/blog.researcher.life\/wp-content\/uploads\/2023\/03\/RPaperpal_BlogBanners-1_01_.png\" alt=\"\" width=\"640\" height=\"139\" srcset=\"https:\/\/blog.researcher.life\/wp-content\/uploads\/2023\/03\/RPaperpal_BlogBanners-1_01_.png 640w, https:\/\/blog.researcher.life\/wp-content\/uploads\/2023\/03\/RPaperpal_BlogBanners-1_01_-300x65.png 300w\" sizes=\"auto, (max-width: 640px) 100vw, 640px\" \/><\/a><\/h2>\n<h2><span class=\"ez-toc-section\" id=\"One-Tailed_vs_Two-Tailed_Tests\"><\/span>One-Tailed vs Two-Tailed Tests<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>When conducting a <a href=\"https:\/\/www.editage.com\/blog\/hypothesis-testing-different-types-for-biomedical-researchers\/\">hypothesis test<\/a>, you must decide whether to use a one-tailed or two-tailed test before you collect your data. This decision affects how your p-value is calculated and interpreted.<\/p>\n<p>A <strong>two-tailed test<\/strong> checks for a difference in either direction: your alternative hypothesis states that the two groups are simply different, without specifying which is larger. The p-value is calculated from both tails of the probability distribution. This is the most common choice when you have no prior reason to expect a result in one particular direction.<\/p>\n<p>A <strong>one-tailed test<\/strong> (also called a directional test) checks for a difference in only one direction. Your alternative hypothesis specifies that one group is either greater than or less than the other. The p-value is calculated from only one tail of the distribution, which means a one-tailed test is more sensitive to detecting an effect in the predicted direction \u2014 but it cannot detect an effect in the opposite direction at all.<\/p>\n<h3><span class=\"ez-toc-section\" id=\"Choosing_between_them\"><\/span>Choosing between them<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<table>\n<thead>\n<tr>\n<td><\/td>\n<td><strong>Two-tailed<\/strong><\/td>\n<td><strong>One-tailed<\/strong><\/td>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>Alternative hypothesis<\/td>\n<td>A \u2260 B<\/td>\n<td>A &gt; B or A &lt; B<\/td>\n<\/tr>\n<tr>\n<td>Direction predicted in advance?<\/td>\n<td>No<\/td>\n<td>Yes<\/td>\n<\/tr>\n<tr>\n<td>More conservative?<\/td>\n<td>Yes<\/td>\n<td>No<\/td>\n<\/tr>\n<tr>\n<td>Risk of missing a reverse effect?<\/td>\n<td>No<\/td>\n<td>Yes<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>In the clinical trial example used throughout this article, because we predicted that the new drug would last <em>longer<\/em> (not just <em>differently<\/em>), an upper-tailed (one-tailed) test is appropriate. If we had simply asked whether the two drugs differed, a two-tailed test would be the safer choice.<\/p>\n<p>As a rule of thumb, use a two-tailed test unless you have a strong theoretical reason to predict the direction of the effect in advance. Using a one-tailed test specifically to achieve a smaller p-value after looking at the data is considered p-hacking and is not acceptable in research.<\/p>\n<p>&nbsp;<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Confidence_Intervals\"><\/span>Confidence Intervals<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>A p-value tells you whether a result is statistically significant, but it does not tell you how large the effect is or how precisely it has been estimated. <a href=\"https:\/\/www.editage.com\/blog\/what-is-confidence-intervals-and-why-is-it-important\/\">Confidence intervals<\/a> provide that missing information, which is why most journals now require them alongside p-values.<\/p>\n<h3><span class=\"ez-toc-section\" id=\"What_is_a_confidence_interval\"><\/span>What is a confidence interval?<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>A <strong>confidence interval (CI)<\/strong> is a range of values that is likely to contain the true population parameter.<\/p>\n<h3><span class=\"ez-toc-section\" id=\"What_does_a_95_confidence_interval_mean\"><\/span>What does a 95% confidence interval mean?<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>A 95% confidence interval means that if you repeated the study 100 times, approximately 95 of those intervals would contain the true value. The width of the interval reflects the precision of your estimate: a narrow interval means a more precise estimate; a wide one reflects more uncertainty, usually due to a small sample size.<\/p>\n<h3><span class=\"ez-toc-section\" id=\"How_confidence_intervals_relate_to_p-values\"><\/span>How confidence intervals relate to p-values<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>There is a direct relationship between confidence intervals and p-values. For a two-tailed test at a significance level of \u03b1 = 0.05:<\/p>\n<ul>\n<li>If a 95% confidence interval does <strong>not<\/strong> include zero (for a difference) or one (for a ratio), the result is statistically significant at <em>p<\/em> &lt; 0.05.<\/li>\n<li>If the interval <strong>does<\/strong> include zero, the result is not statistically significant.<\/li>\n<\/ul>\n<p>Returning to the clinical trial example: suppose the new drug was found to last an average of 3 hours longer than the standard drug, with a 95% CI of [0.8, 5.2] hours. Because the interval does not include zero, this confirms the statistically significant finding. The interval also tells us something the p-value cannot: the true benefit is plausibly anywhere between just under one hour and over five hours longer.<\/p>\n<h3><span class=\"ez-toc-section\" id=\"Why_confidence_intervals_matter\"><\/span>Why confidence intervals matter<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>A p-value can be very small simply because the sample was very large, even when the true effect is trivial. A confidence interval anchors the result to a real-world scale. Reporting the interval allows readers to judge whether a statistically significant result is also <em>practically<\/em> significant. This is something the p-value alone cannot answer. The American Psychological Association (APA) and most major journals now strongly recommend or require the reporting of confidence intervals alongside p-values.<\/p>\n<p>&nbsp;<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Type_I_and_Type_II_Errors\"><\/span>Type I and Type II Errors<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Every hypothesis test carries the risk of reaching the wrong conclusion. There are two distinct ways this can happen, and understanding them is essential for interpreting p-values correctly.<\/p>\n<h3><span class=\"ez-toc-section\" id=\"What_is_a_Type_I_error\"><\/span>What is a Type I error?<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><strong>Type I error (false positive)<\/strong> occurs when you reject the null hypothesis even though it is actually true. In other words, you conclude that an effect exists when in reality it does not. The probability of making a Type I error is equal to your significance level, \u03b1. If you set \u03b1 = 0.05, there is a 5% chance of a false positive even if the null hypothesis is completely true.<\/p>\n<h3><span class=\"ez-toc-section\" id=\"What_is_a_Type_II_error\"><\/span>What is a Type II error?<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><strong>Type II error (false negative)<\/strong> occurs when you fail to reject the null hypothesis even though it is actually false. You conclude there is no effect when in reality one does exist. The probability of a Type II error is denoted \u03b2. It is influenced by sample size, effect size, and the chosen significance level.<\/p>\n<table>\n<thead>\n<tr>\n<td><\/td>\n<td><strong>Null hypothesis is true<\/strong><\/td>\n<td><strong>Null hypothesis is false<\/strong><\/td>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><strong>Reject null hypothesis<\/strong><\/td>\n<td>Type I error (false positive)<\/td>\n<td>Correct decision \u2713<\/td>\n<\/tr>\n<tr>\n<td><strong>Fail to reject null hypothesis<\/strong><\/td>\n<td>Correct decision \u2713<\/td>\n<td>Type II error (false negative)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h3><span class=\"ez-toc-section\" id=\"The_trade-off_between_error_types\"><\/span>The trade-off between error types<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>Reducing the risk of one type of error increases the risk of the other, when sample size is held constant. If you lower the significance threshold from 0.05 to 0.01 to reduce false positives, you simultaneously make it harder to detect real effects, raising the rate of false negatives.<\/p>\n<p>The appropriate balance depends on the consequences of each error type in your field. In clinical research, for example, a false positive (approving an ineffective drug) may be less dangerous than a false negative (failing to detect a life-saving one), or vice versa depending on the intervention.<\/p>\n<h3><span class=\"ez-toc-section\" id=\"Practical_implications\"><\/span>Practical implications<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>When a study reports a non-significant result (<em>p<\/em> &gt; 0.05), this does not mean the null hypothesis is proven true. It may simply mean the study lacked the power to detect the effect. This is a Type II error. This is why <a href=\"https:\/\/www.editage.com\/insights\/an-introduction-to-sample-size-effect-size-and-statistical-power-for-biomedical-researchers\">sample size planning<\/a> and <a href=\"https:\/\/www.editage.com\/insights\/importance-of-statistical-power-in-research-design\">statistical power analysis<\/a> are critical steps before any study begins.<\/p>\n<p>&nbsp;<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Statistical_Power\"><\/span>Statistical Power<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Statistical power is the probability that your hypothesis test will correctly detect a true effect when one exists. In other words, it is the probability of <em>avoiding<\/em> a Type II error. Power is expressed as 1 \u2212 \u03b2, where \u03b2 is the Type II error rate.<\/p>\n<p>A study with 80% power has an 80% chance of detecting a real effect and a 20% chance of missing it. Most researchers aim for a minimum power of 0.80 (80%), though fields with higher stakes, such as clinical trials, often target 0.90 or higher.<\/p>\n<h3><span class=\"ez-toc-section\" id=\"What_determines_statistical_power\"><\/span>What determines statistical power?<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>Four factors interact to determine power:<\/p>\n<ul>\n<li><strong>Sample size<\/strong>: The most controllable factor. Larger samples reduce variability and increase the precision of estimates, making it easier to detect true effects.<\/li>\n<li><strong>Effect size<\/strong>: Larger, more substantial effects are easier to detect than small ones. Power calculations require a pre-specified expected effect size, usually drawn from prior literature or a pilot study.<\/li>\n<li><strong>Significance level (\u03b1)<\/strong>: A stricter threshold (e.g., \u03b1 = 0.01 instead of 0.05) reduces Type I errors but also reduces power.<\/li>\n<li><strong>Variability in the data<\/strong>: Greater spread in the data means more noise, which makes it harder to detect a signal.<\/li>\n<\/ul>\n<h3><span class=\"ez-toc-section\" id=\"Why_power_matters\"><\/span>Why power matters<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>An underpowered study is problematic in two ways. First, it may miss a real effect, wasting resources and potentially delaying beneficial treatments or interventions.<\/p>\n<p>Second, and less intuitively, an underpowered study that <em>does<\/em> achieve significance is more likely to have overestimated the true effect size, because only unusually large effects clear the significance threshold by chance in a small sample. This is known as the &#8220;winner&#8217;s curse&#8221; and contributes to the replication problems discussed below.<\/p>\n<h3><span class=\"ez-toc-section\" id=\"Power_analysis\"><\/span>Power analysis<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>Power analysis should be conducted <em>before<\/em> data collection to determine the minimum sample size needed to detect your expected effect at a given significance level and desired power. Many statistical software packages (G*Power, R, SPSS) include power analysis tools. Reporting the results of a pre-study power calculation is now standard practice in clinical and psychological research.<\/p>\n<p>&nbsp;<\/p>\n<h2><span class=\"ez-toc-section\" id=\"The_Multiple_Comparisons_Problem\"><\/span>The Multiple Comparisons Problem<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>When you perform multiple hypothesis tests within the same study, the probability of making at least one Type I error (false positive) increases substantially, even if each individual test is run at \u03b1 = 0.05. This is known as the <strong>multiple comparisons problem<\/strong>, also called the problem of multiplicity.<\/p>\n<h3><span class=\"ez-toc-section\" id=\"Why_multiple_tests_inflate_the_false_positive_rate\"><\/span>Why multiple tests inflate the false positive rate<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>If you run one test at \u03b1 = 0.05, there is a 5% chance of a false positive. But if you run 20 independent tests, the probability of getting <em>at least one<\/em> false positive (even if no true effects exist) rises to approximately 64%. The overall error rate across a family of tests is called the <strong>familywise error rate (FWER)<\/strong>.<\/p>\n<p>This problem arises in several common situations:<\/p>\n<ul>\n<li>Comparing more than two groups pairwise (e.g., testing Drug A vs Drug B, Drug A vs Drug C, and Drug B vs Drug C separately)<\/li>\n<li>Testing multiple outcome variables in the same study<\/li>\n<li>Running subgroup analyses that were not planned in advance<\/li>\n<li>Repeatedly testing accumulating data and stopping when <em>p<\/em> &lt; 0.05<\/li>\n<\/ul>\n<h3><span class=\"ez-toc-section\" id=\"ANOVA_vs_multiple_t-tests\"><\/span>ANOVA vs multiple t-tests<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>A common example of the multiple comparisons problem occurs when researchers compare three or more groups. Running separate <a href=\"https:\/\/www.editage.com\/insights\/what-biomedical-researchers-need-to-know-about-t-tests\">t-tests<\/a> for each pair of groups inflates the false positive rate. The appropriate solution is a <strong><a href=\"https:\/\/www.editage.com\/blog\/anova-types-uses-assumptions-a-quick-guide-for-biomedical-researchers\/\">one-way ANOVA (Analysis of Variance)<\/a><\/strong>, which tests all groups simultaneously and produces a single p-value for the overall difference. If the ANOVA is significant, <em>post-hoc<\/em> tests (such as Tukey&#8217;s HSD or Bonferroni correction) can then be used to identify which specific groups differ, while controlling the familywise error rate.<\/p>\n<h3><span class=\"ez-toc-section\" id=\"Common_corrections\"><\/span>Common corrections<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>Several methods exist to adjust p-values or significance thresholds when multiple comparisons are made:<\/p>\n<ul>\n<li><strong>Bonferroni correction<\/strong>: Divide \u03b1 by the number of tests (e.g., for 10 tests, use \u03b1 = 0.005). Conservative but simple.<\/li>\n<li><strong>False Discovery Rate (FDR) \/ Benjamini\u2013Hochberg procedure<\/strong>: Controls the expected proportion of false positives among significant results. Less conservative than Bonferroni, commonly used in genomics and neuroimaging.<\/li>\n<\/ul>\n<p>When reading research, always check whether multiple comparisons were made and whether appropriate corrections were applied. Uncorrected multiple comparisons are one of the most common sources of irreproducible findings in the literature.<\/p>\n<p>&nbsp;<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Publication_Bias_and_the_Replication_Crisis\"><\/span>Publication Bias and the Replication Crisis<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Understanding what p-values cannot do is just as important as knowing what they can. Over the past two decades, a growing body of evidence has revealed that an overreliance on p &lt; 0.05 as a binary decision criterion has contributed to a serious <strong>replication crisis<\/strong> across the social sciences, medicine, and psychology.<\/p>\n<h3><span class=\"ez-toc-section\" id=\"Publication_bias\"><\/span>Publication bias<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p><a href=\"https:\/\/www.editage.com\/insights\/publication-and-reporting-biases-and-how-they-impact-publication-of-research\">Publication bias<\/a> refers to the tendency for scientific journals to publish studies with statistically significant results (<em>p<\/em> &lt; 0.05) while rejecting or ignoring studies that fail to reach significance. This creates a distorted picture of the evidence base: the published literature overrepresents positive findings, even though null results are equally valid and informative.<\/p>\n<p>The consequences are significant. When multiple research groups independently study the same question, only those that happen to find <em>p<\/em> &lt; 0.05 are likely to appear in journals. The unpublished null results remain invisible: a phenomenon sometimes called the &#8220;file drawer problem.&#8221; Meta-analyses that rely on published studies alone therefore tend to overestimate the true size of effects.<\/p>\n<h3><span class=\"ez-toc-section\" id=\"The_replication_crisis\"><\/span>The replication crisis<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>Beginning around 2011, large-scale replication projects began systematically re-running published studies. The results were sobering. The Reproducibility Project: Psychology, which attempted to replicate 100 studies published in leading psychology journals, found that only about 36\u201339% reproduced the original significant finding. Similar replication failures have been documented in cancer biology, economics, and medicine.<\/p>\n<p>The causes are multiple and interrelated: publication bias, underpowered studies, p-hacking, hypothesising after results are known (HARKing), and the flexibility researchers have in data collection and analysis. Small p-values in underpowered studies are particularly fragile, because (as discussed above) underpowered studies that achieve significance tend to overestimate effect sizes.<\/p>\n<h3><span class=\"ez-toc-section\" id=\"What_this_means_for_interpreting_p-values\"><\/span>What this means for interpreting p-values<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>A single study reporting <em>p<\/em> &lt; 0.05 is not proof. P-values need to be interpreted in context: the prior plausibility of the hypothesis, the statistical power of the study, whether the analysis was pre-registered, and whether the result has been independently replicated. Many statisticians and scientific organisations now recommend supplementing or replacing p-value thresholds with effect sizes, confidence intervals, <a href=\"https:\/\/www.editage.com\/insights\/10-steps-to-get-started-with-bayesian-statistics-in-biomedical-research\">Bayesian approaches<\/a>, or pre-registered replication as the gold standard of evidence.<\/p>\n<p>In 2019, over 800 scientists signed a call in <em>Nature<\/em> to abandon the use of &#8220;statistical significance&#8221; as a binary label, arguing it has been systematically misused and misunderstood. While the debate continues, the consensus is clear: <em>p<\/em> &lt; 0.05 is a starting point for evidence, not a finish line.<\/p>\n<h3><span class=\"ez-toc-section\" id=\"Reporting_non-significant_results\"><\/span>Reporting non-significant results<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>Non-significant results should be reported fully, not omitted or described vaguely. Write, for example: &#8220;There was no significant difference in test scores between the two groups, <em>t<\/em>(58) = 1.14, <em>p<\/em> = .259, <em>d<\/em> = 0.29, 95% CI [\u22120.52, 1.90].&#8221; Reporting the effect size and confidence interval is especially important in <a href=\"https:\/\/www.editage.com\/insights\/how-can-i-publish-negative-results\">null results<\/a>, as they indicate whether the study had sufficient precision to detect a meaningful effect if one existed.<\/p>\n<h3><span class=\"ez-toc-section\" id=\"Pre-registration_and_the_methods_section\"><\/span>Pre-registration and the methods section<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>The significance threshold you used (e.g., \u03b1 = .05) should be declared in the methods section, not chosen after viewing the results. A sentence such as &#8220;The significance threshold was set at \u03b1 = .05 prior to data collection&#8221; is standard practice and signals to reviewers that the analysis was not adjusted post hoc.<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Reporting_P-Values_in_APA_Format\"><\/span>Reporting P-Values in APA Format<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>When writing up research for publication, p-values must be reported clearly and consistently. The <a href=\"https:\/\/www.editage.com\/insights\/cheat-sheet-american-psychological-association-manual-of-style\">Publication Manual of the American Psychological Association (APA, 7th edition)<\/a> provides the most widely adopted guidelines for reporting statistical results, and most peer-reviewed journals in the social and health sciences require or recommend following them.<\/p>\n<h3><span class=\"ez-toc-section\" id=\"General_formatting_rules\"><\/span>General formatting rules<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<ul>\n<li>The letter <em>p<\/em> is always italicised.<\/li>\n<li>P-values are reported without a leading zero: write <em>p<\/em> = .032, not <em>p<\/em> = 0.032.<\/li>\n<li>Spaces appear on both sides of the equals sign: <em>p<\/em> = .05, not <em>p<\/em>=.05.<\/li>\n<li>Very small p-values are reported as <em>p<\/em> &lt; .001 rather than as an exact value (e.g., <em>p<\/em> = .0000032).<\/li>\n<li>Exact p-values are preferred over inequalities wherever software reports them: write <em>p<\/em> = .043, not <em>p<\/em> &lt; .05.<\/li>\n<li>Round to two or three decimal places; never report more precision than your software provides meaningfully.<\/li>\n<\/ul>\n<h3><span class=\"ez-toc-section\" id=\"What_to_report_alongside_the_p-value\"><\/span>What to report alongside the p-value<span class=\"ez-toc-section-end\"><\/span><\/h3>\n<p>A p-value reported in isolation gives readers very little information. APA guidelines require reporting the test statistic, degrees of freedom, and effect size alongside the p-value. Confidence intervals are strongly recommended.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"Worked_example_independent_samples_t-test\"><\/span>Worked example: independent samples t-test<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Suppose a study compared anxiety scores between two groups: one receiving a new intervention (<em>n<\/em> = 45) and a control group (<em>n<\/em> = 42). After conducting an independent samples t-test, the results might be reported as follows:<\/p>\n<p>Participants in the intervention group (<em>M<\/em> = 14.2, <em>SD<\/em> = 3.8) reported significantly lower anxiety than those in the control group (<em>M<\/em> = 17.6, <em>SD<\/em> = 4.1), <em>t<\/em>(85) = \u22124.21, <em>p<\/em> &lt; .001, <em>d<\/em> = 0.86, 95% CI [\u22125.01, \u22121.79].<\/p>\n<p>Breaking this down:<\/p>\n<table>\n<thead>\n<tr>\n<td><strong>Element<\/strong><\/td>\n<td><strong>Meaning<\/strong><\/td>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td><em>M<\/em> = 14.2, <em>SD<\/em> = 3.8<\/td>\n<td>Group mean and standard deviation<\/td>\n<\/tr>\n<tr>\n<td><em>t<\/em>(85) = \u22124.21<\/td>\n<td>t-statistic with degrees of freedom in parentheses<\/td>\n<\/tr>\n<tr>\n<td><em>p<\/em> &lt; .001<\/td>\n<td>P-value (exact value too small to report as decimal)<\/td>\n<\/tr>\n<tr>\n<td><em>d<\/em> = 0.86<\/td>\n<td>Cohen&#8217;s d effect size (large effect)<\/td>\n<\/tr>\n<tr>\n<td>95% CI [\u22125.01, \u22121.79]<\/td>\n<td>Confidence interval for the mean difference<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p>&nbsp;<\/p>\n<h2 aria-level=\"2\"><span class=\"ez-toc-section\" id=\"Frequently_Asked_Questions_FAQs_on_p-value\"><\/span><span data-contrast=\"none\">Frequently Asked Questions (FAQs) on p-value<\/span><span data-ccp-props=\"{&quot;134245418&quot;:true,&quot;134245529&quot;:true,&quot;201341983&quot;:0,&quot;335559738&quot;:40,&quot;335559739&quot;:0,&quot;335559740&quot;:240}\">\u00a0<\/span><span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p><b><span data-contrast=\"none\">Q: What influences p-value?\u00a0<\/span><\/b><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:0,&quot;335559740&quot;:240}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"none\">The primary factors that affect <\/span><span data-contrast=\"none\">p-value in statistics<\/span><span data-contrast=\"none\"> include the size of the observed effect, sample size, variability within the data, and the chosen significance level (alpha). A larger effect size, a larger sample size, lower variability, and a lower significance level can all contribute to a lower p-value, indicating stronger evidence against the null hypothesis.<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:0,&quot;335559740&quot;:240}\">\u00a0<\/span><\/p>\n<p><b><span data-contrast=\"none\">Q: What does p-value of 0.05 mean?\u00a0<\/span><\/b><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:0,&quot;335559740&quot;:240}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"none\">A p-value of 0.05 is a commonly used threshold in statistical hypothesis testing. It represents the level of significance, typically denoted as alpha, which is the probability of rejecting the null hypothesis when it is true. If the p-value is less than or equal to 0.05, it suggests that the observed results are statistically significant at the 5% level, meaning they are unlikely to occur by chance alone.<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:0,&quot;335559740&quot;:240}\">\u00a0<\/span><\/p>\n<p><b><span data-contrast=\"none\">Q: What is the <\/span><\/b><b><span data-contrast=\"none\">p-value significance<\/span><\/b><b><span data-contrast=\"none\"> of 0.15?<\/span><\/b><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:0,&quot;335559740&quot;:240}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"none\">The significance of a p-value depends on the chosen threshold, typically called the significance level or alpha. If the significance level is set at 0.05, a p-value of 0.15 would not be considered statistically significant. In this case, there is insufficient evidence to reject the null hypothesis. However, it is important to note that significance levels can vary depending on the specific field or study design.<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:0,&quot;335559740&quot;:240}\">\u00a0<\/span><\/p>\n<p><b><span data-contrast=\"none\">Q: Which p-value to use in T-Test?\u00a0<\/span><\/b><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:0,&quot;335559740&quot;:240}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"none\">When performing a T-Test, the p-value obtained indicates the probability of observing the data if the null hypothesis is true. The appropriate p-value to use in a T-Test is based on the chosen significance level (alpha). Generally, a p-value less than or equal to the alpha indicates statistical significance, supporting the rejection of the null hypothesis in favour of the alternative hypothesis.<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:0,&quot;335559740&quot;:240}\">\u00a0<\/span><\/p>\n<p><b><span data-contrast=\"none\">Q: Are p-values affected by sample size?\u00a0<\/span><\/b><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:0,&quot;335559740&quot;:240}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"none\">Yes, sample size can influence p-values. Larger sample sizes tend to yield more precise estimates and narrower confidence intervals. This increased precision can affect the p-value calculations, making it easier to detect smaller effects or subtle differences between groups or variables. This can potentially lead to smaller p-values, indicating statistical significance. However, it&#8217;s important to note that sample size alone is not the sole determinant of statistical significance. Consider it along with other factors, such as effect size, variability, and chosen significance level (alpha), when determining the p-value.<\/span><span data-ccp-props=\"{&quot;201341983&quot;:0,&quot;335559739&quot;:0,&quot;335559740&quot;:240}\">\u00a0<\/span><\/p>\n<p><i><span data-contrast=\"auto\">Editage All Access<\/span><\/i><i><span data-contrast=\"auto\"> is a subscription-based platform that unifies the best AI tools and services designed to speed up, simplify, and streamline every step of a researcher\u2019s journey. The <\/span><\/i><a href=\"https:\/\/researcher.life\/?utm_source=contentmarketing&amp;utm_medium=rblog&amp;utm_campaign=what-is-p-value-calculation-statistical-significance-boilerplate\"><b><i><span data-contrast=\"none\">Editage All Access Pack<\/span><\/i><\/b><\/a> <i><span data-contrast=\"auto\">is a one-of-a-kind subscription that unlocks full access to an AI writing assistant, literature recommender, journal finder, scientific illustration tool, and exclusive discounts on professional publication services from Editage.<\/span><\/i><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;201341983&quot;:0,&quot;335551550&quot;:1,&quot;335551620&quot;:1,&quot;335559738&quot;:0,&quot;335559739&quot;:240,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<p><i><span data-contrast=\"auto\">Based on 22+ years of experience in academia, <\/span><\/i><i><span data-contrast=\"auto\">Editage All Access<\/span><\/i><i><span data-contrast=\"auto\"> empowers researchers to put their best research forward and move closer to success. Explore our top AI Tools pack, AI Tools + Publication Services pack, or Build Your Own Plan. Find everything a researcher needs to succeed, all in one place \u2013\u202f<\/span><\/i><a href=\"https:\/\/researcher.life\/all-access-pricing?utm_source=contentmarketing&amp;utm_medium=rblog&amp;utm_campaign=what-is-p-value-calculation-statistical-significance-boilerplate\"><b><i><span data-contrast=\"none\">Get All Access now starting at just <\/span><\/i><\/b><b><i><span data-contrast=\"none\">$14<\/span><\/i><\/b><b><i><span data-contrast=\"none\"> a month<\/span><\/i><\/b><\/a><b><i><span data-contrast=\"auto\">!<\/span><\/i><\/b><span data-contrast=\"auto\">\u202f<\/span><span data-ccp-props=\"{&quot;134233117&quot;:false,&quot;134233118&quot;:false,&quot;201341983&quot;:0,&quot;335551550&quot;:1,&quot;335551620&quot;:1,&quot;335559738&quot;:0,&quot;335559739&quot;:240,&quot;335559740&quot;:259}\">\u00a0<\/span><\/p>\n<p>This article was originally published on February 9, 2023, and updated on June 8, 2026.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u201cWhat is a p-value?\u201d are words often uttered by early career researchers and sometimes even by more experienced ones. The p-value is an important and<\/p>\n","protected":false},"author":37,"featured_media":5120,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_editorskit_title_hidden":false,"_editorskit_reading_time":0,"_editorskit_is_block_options_detached":false,"_editorskit_block_options_position":"{}","footnotes":""},"categories":[488,489,1],"tags":[12,45,522,31,67,508],"class_list":["post-5118","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-academic-writing","category-getting-published","category-researcher-life","tag-academic-writing","tag-manuscript-writing","tag-p-value","tag-research-paper","tag-scientific-research","tag-tips-for-researchers"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.9 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>What is p-value: How to Calculate It and Statistical Significance | Researcher.Life<\/title>\n<meta name=\"description\" content=\"The p-value is an important concept in quantitative research that can be confusing and easily misused. In this comprehensive article, we take a deeper look at what is a p-value, how to calculate it, and its statistical significance in research. Read more!\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/researcher.life\/blog\/article\/what-is-p-value-calculation-statistical-significance\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"What is p-value: How to Calculate It and Statistical Significance | Researcher.Life\" \/>\n<meta property=\"og:description\" content=\"The p-value is an important concept in quantitative research that can be confusing and easily misused. In this comprehensive article, we take a deeper look at what is a p-value, how to calculate it, and its statistical significance in research. Read more!\" \/>\n<meta property=\"og:url\" content=\"https:\/\/researcher.life\/blog\/article\/what-is-p-value-calculation-statistical-significance\/\" \/>\n<meta property=\"article:published_time\" content=\"2026-06-08T02:22:05+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-06-08T09:26:11+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/blog.researcher.life\/wp-content\/uploads\/2023\/02\/hero4.png\" \/>\n\t<meta property=\"og:image:width\" content=\"624\" \/>\n\t<meta property=\"og:image:height\" content=\"417\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Jennifer Ulz\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Jennifer Ulz\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"22 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\/\/researcher.life\/blog\/article\/what-is-p-value-calculation-statistical-significance\/#article\",\"isPartOf\":{\"@id\":\"https:\/\/researcher.life\/blog\/article\/what-is-p-value-calculation-statistical-significance\/\"},\"author\":{\"name\":\"Jennifer Ulz\",\"@id\":\"https:\/\/researcher.life\/blog\/#\/schema\/person\/57ac57ac69929b0fe0689e6c5e87ab24\"},\"headline\":\"What is p-value: How to Calculate It and Statistical Significance\",\"datePublished\":\"2026-06-08T02:22:05+00:00\",\"dateModified\":\"2026-06-08T09:26:11+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\/\/researcher.life\/blog\/article\/what-is-p-value-calculation-statistical-significance\/\"},\"wordCount\":4793,\"image\":{\"@id\":\"https:\/\/researcher.life\/blog\/article\/what-is-p-value-calculation-statistical-significance\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/blog.researcher.life\/wp-content\/uploads\/2023\/02\/hero4.png\",\"keywords\":[\"Academic Writing\",\"Manuscript writing\",\"p-value\",\"Research Paper\",\"Scientific research\",\"tips for researchers\"],\"articleSection\":[\"Academic Writing\",\"Getting Published\",\"Researcher.Life\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/researcher.life\/blog\/article\/what-is-p-value-calculation-statistical-significance\/\",\"url\":\"https:\/\/researcher.life\/blog\/article\/what-is-p-value-calculation-statistical-significance\/\",\"name\":\"What is p-value: How to Calculate It and Statistical Significance | Researcher.Life\",\"isPartOf\":{\"@id\":\"https:\/\/researcher.life\/blog\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/researcher.life\/blog\/article\/what-is-p-value-calculation-statistical-significance\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/researcher.life\/blog\/article\/what-is-p-value-calculation-statistical-significance\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/blog.researcher.life\/wp-content\/uploads\/2023\/02\/hero4.png\",\"datePublished\":\"2026-06-08T02:22:05+00:00\",\"dateModified\":\"2026-06-08T09:26:11+00:00\",\"author\":{\"@id\":\"https:\/\/researcher.life\/blog\/#\/schema\/person\/57ac57ac69929b0fe0689e6c5e87ab24\"},\"description\":\"The p-value is an important concept in quantitative research that can be confusing and easily misused. In this comprehensive article, we take a deeper look at what is a p-value, how to calculate it, and its statistical significance in research. Read more!\",\"breadcrumb\":{\"@id\":\"https:\/\/researcher.life\/blog\/article\/what-is-p-value-calculation-statistical-significance\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/researcher.life\/blog\/article\/what-is-p-value-calculation-statistical-significance\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/researcher.life\/blog\/article\/what-is-p-value-calculation-statistical-significance\/#primaryimage\",\"url\":\"https:\/\/blog.researcher.life\/wp-content\/uploads\/2023\/02\/hero4.png\",\"contentUrl\":\"https:\/\/blog.researcher.life\/wp-content\/uploads\/2023\/02\/hero4.png\",\"width\":\"624\",\"height\":\"417\",\"caption\":\"What is p-value: How to calculate it and statistical significance\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/researcher.life\/blog\/article\/what-is-p-value-calculation-statistical-significance\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/researcher.life\/blog\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Researcher.Life\",\"item\":\"https:\/\/researcher.life\/blog\/category\/researcher-life\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"What is p-value: How to Calculate It and Statistical Significance\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/researcher.life\/blog\/#website\",\"url\":\"https:\/\/researcher.life\/blog\/\",\"name\":\"\",\"description\":\"Educational resources and simple solutions for your research journey\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/researcher.life\/blog\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/researcher.life\/blog\/#\/schema\/person\/57ac57ac69929b0fe0689e6c5e87ab24\",\"name\":\"Jennifer Ulz\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\/\/researcher.life\/blog\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/e6f7cf413cf67eee2041bd8887c08e41ed9810f02e426a2b936d8ea11cb705bc?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/e6f7cf413cf67eee2041bd8887c08e41ed9810f02e426a2b936d8ea11cb705bc?s=96&d=mm&r=g\",\"caption\":\"Jennifer Ulz\"},\"url\":\"https:\/\/researcher.life\/blog\/article\/author\/jennifer_ulz\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"What is p-value: How to Calculate It and Statistical Significance | Researcher.Life","description":"The p-value is an important concept in quantitative research that can be confusing and easily misused. In this comprehensive article, we take a deeper look at what is a p-value, how to calculate it, and its statistical significance in research. Read more!","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/researcher.life\/blog\/article\/what-is-p-value-calculation-statistical-significance\/","og_locale":"en_US","og_type":"article","og_title":"What is p-value: How to Calculate It and Statistical Significance | Researcher.Life","og_description":"The p-value is an important concept in quantitative research that can be confusing and easily misused. In this comprehensive article, we take a deeper look at what is a p-value, how to calculate it, and its statistical significance in research. Read more!","og_url":"https:\/\/researcher.life\/blog\/article\/what-is-p-value-calculation-statistical-significance\/","article_published_time":"2026-06-08T02:22:05+00:00","article_modified_time":"2026-06-08T09:26:11+00:00","og_image":[{"width":624,"height":417,"url":"https:\/\/blog.researcher.life\/wp-content\/uploads\/2023\/02\/hero4.png","type":"image\/png"}],"author":"Jennifer Ulz","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Jennifer Ulz","Est. reading time":"22 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/researcher.life\/blog\/article\/what-is-p-value-calculation-statistical-significance\/#article","isPartOf":{"@id":"https:\/\/researcher.life\/blog\/article\/what-is-p-value-calculation-statistical-significance\/"},"author":{"name":"Jennifer Ulz","@id":"https:\/\/researcher.life\/blog\/#\/schema\/person\/57ac57ac69929b0fe0689e6c5e87ab24"},"headline":"What is p-value: How to Calculate It and Statistical Significance","datePublished":"2026-06-08T02:22:05+00:00","dateModified":"2026-06-08T09:26:11+00:00","mainEntityOfPage":{"@id":"https:\/\/researcher.life\/blog\/article\/what-is-p-value-calculation-statistical-significance\/"},"wordCount":4793,"image":{"@id":"https:\/\/researcher.life\/blog\/article\/what-is-p-value-calculation-statistical-significance\/#primaryimage"},"thumbnailUrl":"https:\/\/blog.researcher.life\/wp-content\/uploads\/2023\/02\/hero4.png","keywords":["Academic Writing","Manuscript writing","p-value","Research Paper","Scientific research","tips for researchers"],"articleSection":["Academic Writing","Getting Published","Researcher.Life"],"inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/researcher.life\/blog\/article\/what-is-p-value-calculation-statistical-significance\/","url":"https:\/\/researcher.life\/blog\/article\/what-is-p-value-calculation-statistical-significance\/","name":"What is p-value: How to Calculate It and Statistical Significance | Researcher.Life","isPartOf":{"@id":"https:\/\/researcher.life\/blog\/#website"},"primaryImageOfPage":{"@id":"https:\/\/researcher.life\/blog\/article\/what-is-p-value-calculation-statistical-significance\/#primaryimage"},"image":{"@id":"https:\/\/researcher.life\/blog\/article\/what-is-p-value-calculation-statistical-significance\/#primaryimage"},"thumbnailUrl":"https:\/\/blog.researcher.life\/wp-content\/uploads\/2023\/02\/hero4.png","datePublished":"2026-06-08T02:22:05+00:00","dateModified":"2026-06-08T09:26:11+00:00","author":{"@id":"https:\/\/researcher.life\/blog\/#\/schema\/person\/57ac57ac69929b0fe0689e6c5e87ab24"},"description":"The p-value is an important concept in quantitative research that can be confusing and easily misused. In this comprehensive article, we take a deeper look at what is a p-value, how to calculate it, and its statistical significance in research. Read more!","breadcrumb":{"@id":"https:\/\/researcher.life\/blog\/article\/what-is-p-value-calculation-statistical-significance\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/researcher.life\/blog\/article\/what-is-p-value-calculation-statistical-significance\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/researcher.life\/blog\/article\/what-is-p-value-calculation-statistical-significance\/#primaryimage","url":"https:\/\/blog.researcher.life\/wp-content\/uploads\/2023\/02\/hero4.png","contentUrl":"https:\/\/blog.researcher.life\/wp-content\/uploads\/2023\/02\/hero4.png","width":"624","height":"417","caption":"What is p-value: How to calculate it and statistical significance"},{"@type":"BreadcrumbList","@id":"https:\/\/researcher.life\/blog\/article\/what-is-p-value-calculation-statistical-significance\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/researcher.life\/blog\/"},{"@type":"ListItem","position":2,"name":"Researcher.Life","item":"https:\/\/researcher.life\/blog\/category\/researcher-life\/"},{"@type":"ListItem","position":3,"name":"What is p-value: How to Calculate It and Statistical Significance"}]},{"@type":"WebSite","@id":"https:\/\/researcher.life\/blog\/#website","url":"https:\/\/researcher.life\/blog\/","name":"","description":"Educational resources and simple solutions for your research journey","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/researcher.life\/blog\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Person","@id":"https:\/\/researcher.life\/blog\/#\/schema\/person\/57ac57ac69929b0fe0689e6c5e87ab24","name":"Jennifer Ulz","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/researcher.life\/blog\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/e6f7cf413cf67eee2041bd8887c08e41ed9810f02e426a2b936d8ea11cb705bc?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/e6f7cf413cf67eee2041bd8887c08e41ed9810f02e426a2b936d8ea11cb705bc?s=96&d=mm&r=g","caption":"Jennifer Ulz"},"url":"https:\/\/researcher.life\/blog\/article\/author\/jennifer_ulz\/"}]}},"jetpack_featured_media_url":"https:\/\/blog.researcher.life\/wp-content\/uploads\/2023\/02\/hero4.png","_links":{"self":[{"href":"https:\/\/researcher.life\/blog\/wp-json\/wp\/v2\/posts\/5118","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/researcher.life\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/researcher.life\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/researcher.life\/blog\/wp-json\/wp\/v2\/users\/37"}],"replies":[{"embeddable":true,"href":"https:\/\/researcher.life\/blog\/wp-json\/wp\/v2\/comments?post=5118"}],"version-history":[{"count":7,"href":"https:\/\/researcher.life\/blog\/wp-json\/wp\/v2\/posts\/5118\/revisions"}],"predecessor-version":[{"id":12630,"href":"https:\/\/researcher.life\/blog\/wp-json\/wp\/v2\/posts\/5118\/revisions\/12630"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/researcher.life\/blog\/wp-json\/wp\/v2\/media\/5120"}],"wp:attachment":[{"href":"https:\/\/researcher.life\/blog\/wp-json\/wp\/v2\/media?parent=5118"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/researcher.life\/blog\/wp-json\/wp\/v2\/categories?post=5118"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/researcher.life\/blog\/wp-json\/wp\/v2\/tags?post=5118"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}